Demonstration of cross-reactivity between bacterial antigens and class I human leukocyte antigens by using monoclonal antibodies to Shigella flexneri
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چکیده
منابع مشابه
Demonstration of cross-reactivity between bacterial antigens and class I human leukocyte antigens by using monoclonal antibodies to Shigella flexneri.
Bacterial envelope proteins which share immunodeterminants with the human leukocyte antigen (HLA) class I histocompatibility antigen HLA-B27 may invoke spondyloarthritic disease through the process of molecular mimicry in patients expressing this phenotype. Monoclonal antibodies generated by the immunization of BALB/c mice with envelope proteins of Shigella flexneri type 2a were tested for reac...
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متن کامل3. Antibodies and antigens: cross-reactivity before monoclonal antibodies 4. Antibodies and antigens: cross-reactivity after monoclonal antibodies 5. Cross-reactivity and the molecular mimicry hypothesis 6. Cross-reactivity and the phenomenon of microbial escape from immune surveillance
1. Abstract 2. Introduction: the “vaccine problem” 3. Antibodies and antigens: cross-reactivity before monoclonal antibodies 4. Antibodies and antigens: cross-reactivity after monoclonal antibodies 5. Cross-reactivity and the molecular mimicry hypothesis 6. Cross-reactivity and the phenomenon of microbial escape from immune surveillance 7. Peptide commonality, immune escape, adjuvanted vaccines...
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A temperate phage, designated Sf6, has been isolated from Shigella flexneri 3a. Characterization of Sf6 revealed that it possesses the capacity for converting the S. flexneri 3,4 group antigen complex to group factor 6. Serological studies and chemical analysis of lipopolysaccharide from converted strains suggest that group factor 6 is a reflection of an acetylation of the preexisting 3,4 antig...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1990
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.58.6.1774-1781.1990